Welcome to Team NAGASAKI Digital Medical AI DIGIMA Labo Pages

ようこそチーム長崎AIラボへ

Team member Yasuhiko Nakao, Ryou Sasaki, Fumihiro Mawatari, Yuko Akazawa, Maiko Tabuchi, Ayumu Shiroo, Saki Shimada, Eriko Nakao

科研費を獲得し研究活動を行なっております。 https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K17997/

医療データから深層学習を用いて患者様や医療従事者に役に立つAIアプリの開発をおこなっています。

現在進行中のプロジェクト

# 救急医療における深層学習を用いた腹部CT画像AI診断補助システムの開発 
# NST(Nutrition Suport Team)へ応用可能な医療AIアプリの開発
# 看護師向けの医療サポートとして経鼻胃管挿入位置に対する胃音の異常検知モデル
# Openposeによる関節運動評価を取り入れた理学療法の1例
# “食道アカラシア”の病態評価に用いられる食道内圧計High-resolution esophageal manometry（HREM）に対する食道アカラシアAI診断補助モデル
# bioinformatics 病理検体とエクソソーム（前述）を関連させた空間シングルセルオミクス診断システム
# clinical research

Yasuhiko Nakao M.D. PhD https://researchmap.jp/Y.Nakao

R　Python Pytorch fastai C#を使用したdeep learningを含む機械学習系の医療応用に関する研究開発をおこなっています。趣味は筋トレ、散歩、卓球です。

Department of Gastroenterology and Hepatology Nagasaki University 1-7-1 Sakamoto, Nagasaki, 852-8501 Tel: 507 284 0686; Fax: 507 284 0762 yasuhiko.dream.new.york@gmail.com

発表論文

1） Nakao, Y., Fukushima, M., Mauer, A. S., Liao, C. Y., Ferris, A., Dasgupta, D., Heppelmann, C. J., Vanderboom, P. M., Saraswat, M., Pandey, A., Nair, K. S., Allen, A. M., Nakao, K., & Malhi, H. (2021). A Comparative Proteomic Analysis of Extracellular Vesicles Associated With Lipotoxicity. Front Cell Dev Biol, 9, 735001. https://doi.org/10.3389/fcell.2021.735001

2） Nakao, Y., Amrollahi, P., Parthasarathy, G., Mauer, A. S., Sehrawat, T. S., Vanderboom, P., Nair, K. S., Nakao, K., Allen, A. M., Hu, T. Y., & Malhi, H. (2021). Circulating extracellular vesicles are a biomarker for NAFLD resolution and response to weight loss surgery. Nanomedicine, 36, 102430. https://doi.org/10.1016/j.nano. 2021.102430

3） Tang, H., Li, J., Zinker, B., Boehm, S., Mauer, A., Rex-Rabe, S., Glaser, K. J., Fronheiser, M., Bradstreet, T., Nakao, Y., Petrone, T., Pena, A., Villano, M., Chow, P., Malhi, H., Charles, E. D., Hayes, W., Ehman, R. L., Du, S., & Yin, M. (2022). Evaluation of a PEGylated Fibroblast Growth Factor 21 Variant Using Novel Preclinical Magnetic Resonance Imaging and Magnetic Resonance Elastography in a Mouse Model of Nonalcoholic Steatohepatitis. J Magn Reson Imaging. https://doi.org/10.1002/jmri.28077

4） Furuta, K., Guo, Q., Pavelko, K. D., Lee, J. H., Robertson, K. D., Nakao, Y., Melek, J., Shah, V. H., Hirsova, P., & Ibrahim, S. H. (2021). Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis. J Clin Invest, 131(6). https://doi.org/10.1172/JCI143690

5） Dasgupta, D., Nakao, Y., Mauer, A. S., Thompson, J. M., Sehrawat, T. S., Liao, C. Y., Krishnan, A., Lucien, F., Guo, Q., Liu, M., Xue, F., Fukushima, M., Katsumi, T., Bansal, A., Pandey, M. K., Maiers, J. L., DeGrado, T., Ibrahim, S. H., Revzin, A., Pavelko, K. D., Barry, M. A., Kaufman, R. J., & Malhi, H. (2020). IRE1A Stimulates Hepatocyte-Derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis. Gastroenterology, 159(4), 1487-1503 e1417. https://doi.org/10.1053/j.gastro.2020.06.031

6） Sehrawat, T. S., Arab, J. P., Liu, M., Amrollahi, P., Wan, M., Fan, J., Nakao, Y., Pose, E., Navarro-Corcuera, A., Dasgupta, D., Liao, C. Y., He, L., Mauer, A. S., Avitabile, E., Ventura-Cots, M., Bataller, R. A., Sanyal, A. J., Chalasani, N. P., Heimbach, J. K., Watt, K. D., Gores, G. J., Gines, P., Kamath, P. S., Simonetto, D. A., Hu, T. Y., Shah, V. H., & Malhi, H. (2021). Circulating Extracellular Vesicles Carrying Sphingolipid Cargo for the Diagnosis and Dynamic Risk Profiling of Alcoholic Hepatitis. Hepatology, 73(2), 571-585. https://doi.org/ 10.1002/hep.31256

7） Guicciardi, M. E., Nakao, Y., & Gores, G. J. (2020). The Metabolic Sensor Adenosine MonophosphateActivated Protein Kinase Regulates Apoptosis in Nonalcoholic Steatohepatitis. Hepatology, 72(3), 1139-1141. https://doi.org/10.1002/hep.31294

8） Haraguchi, M., Miuma, S., Yamamoto, K., Nakao, Y., Ichikawa, T., Kanda, Y., Sasaki, R., Fukushima, M., Akazawa, Y., Miyaaki, H., & Nakao, K. (2021). Geranylgeranylacetone decreases the production of hepatitis B virus-related antigen by comprehensive downregulation of mRNA transcription activity. J Gastroenterol Hepatol, 36(7), 1979-1987. https://doi.org/10.1111/jgh.15394

9） Nakao, Y., Hashimoto, S., Abiru, S., Komori, A., Yamasaki, K., Nagaoka, S., Saeki, A., Bekki, S., Kugiyama, Y., Kuroki, T., Ito, M., Nakao, K., & Yatsuhashi, H. (2018). Rapidly growing, moderately differentiated HCC: A clinicopathological characteristic of HCC occurrence after IFN-free DAA therapy? J Hepatol, 68(4), 854-855. https://doi.org/10.1016/j.jhep.2017.11.011

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